Promethazine

Laboratory Report # 3.2 Title:         Promethazine 0.2% Syrup          appointment:                   learner Name: 1.         Describe the dispensing directions for the preparation:         A. Indication and evaluate motion:                           Promethazine HCL is a powerful antihistamine drug employ to track allergic conditions and,                  because of the sedative action, insomnia. It is also utilise as an anti-tussive in cough mixings.         Promethazine can be administered by emit or injection.         B. Directions/administration/use: Sig:         TAKE ane teaspoonful OF SYRUP BY MOUTH AT MEALTIMES AND AT BEDTIME.         C. Precautions/DI: elapse medication out of r distributively of children Do non confuse alcohol while on t his medication Contraindications: ·         children chthonian 2yrs ·         SC or intra-arterial injection ·         narrow-angle glaucoma ·         prostatic hypertrophy ·         bladder or pyeloduodenal obstruction ·         MAOI therapy ·         hypersensitivity to promethazine and other phenothiazines unseemly Reactions: drowsiness dizziness ·         xerostomia ·          surpluspyramidal reactions                  Drug Interactions: belladonna benztropine cabergoline cisapride dofetilide gatifloxacin grepafloxacin halofantrine levofloxacin lithium meperidine hydrochloride moxifloxacin orphenadrine pimozide porfimer procyclidine sotalol sparfloxacin tramadol trihexyphenidyl          D. Storage: Keep the syrup at direction temperature, away from heat, light, and moisture. Do not freeze.         E. disoriented paneling! : Use your medicine as soon as you commend that you have missed your sexually transmitted disease. If it is nearly time for your future(a) dose, hold back until thence to use the medicine and burn the missed dose. You should not use two doses at mavin time. 2.         Purpose of each excipient used in the experiment: drinking chocolate         -         flavoring mover Sucrose         -         sweetening doer, suspending and viscosity-increasing agent. gas Glucose         -         to set up calories, taste, and to improve cristal of atomic number 11                                    and peeing across the intestinal barrier through osmosis          Glycerin         -         used as a demulcent in cough preparations for comfort and protecting                            the mucous membranes and relieves irritation. When administered by                            backtalk or parenterally, glycerine increases the plasma osmolality,                           resulting in the movement of water by osmosis from the extra vascular                           spaces into the plasma. atomic number 11 Chloride-         electrolyte - source of sodium (Na+), used in combination with glucose for oral rehydration in shrewd diarrhea. Vanillin         -         flavoring/perfuming agent Sodium Benzoate         preservative with antibacterial and anti-fungal properties complete(a) Water         -         diluent 3.          designate your calculations and compounding (in steps):         Calculatio ns: Promethazine HCL         2 g Â!  Â Â Â Â Â Â Â          x         (90mL / mmL)         =         0.18 g Cocoa         180 g         x         (90mL / 1000mL)         =         16.

2 g Sucrose         600 g         x         (90mL / 1000mL)         =         54 g Liquid Glucose         180 g         x         (90mL / 1000mL)         =         16.2 g Glycerin         50 mL         x         (9 0mL / 1000mL)         =         4.5 mL x (1.25g/mL) = 5.625 g Sodium Chloride         2.0 g         x         (90mL / 1000mL)         =         0.18g sp. gravity Vanillin         0.2 g         x         (90mL / 1000mL)         =         0.018 g Sodium Benzoate         1.0 g         x         (90mL / 1000mL)         =         0.09 g P. Water         1000 mL         x         (90mL / 1000mL)         =         90 mL Ft. 90 mL         Promethazine:         (2 g / 1000 mL)         x 100 % = 0.2% syrup         1 Tsp = 5 mL x (0.2 % / 100 %) = 0.01 g x (1000 mg / 1 g) = 10 mg / dose Preparation: The sucrose and cocoa were merge together in a beaker. To this smor! gasbord, the glucose, glycerin and vanillin were gradually added. The sodium benzoate and sodium chloride were then dissolved in a undersize amount (30 mL) of naughty water. The promethazine HCL was then added to the solution and was complex well. The contents were then transferred to the mixture in the beaker. The entire mixture was brought to a churn and the boiling temperature was maintained for 2 minutes. The mixture was allowed to cool to room temperature and the volume was brought up to 90 mL by adding spare pure water. If you want to get a full essay, say it on our website: BestEssayCheap.com

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